Subtype-Dependent Co-receptor Tropism in Cuban HIV-1–Infected Patients: Implications for Maraviroc Treatment

INTRODUCTION Unlike most high-income countries where subtype B viruses predominate, the Cuban HIV-1 epidemic is characterized by a great diversity of subtypes and circulating recombinant forms. Some studies have shown that HIV variants exhibiting preference for CXCR4 co-receptor (X4-tropic) could impacts on disease pathogenesis, with clinical implications antiviral treatment plans. Determination tropism crucial clinicians in deciding whether maraviroc an appropriate antiviral.